Molestar muchísimo a alguien.
To annoy someone deeply.
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See how the word “sacar de quicio” is used in sentences
Su tarareo me saca de quicio. — His humming gets under my skin.
¿Por qué su tono me saca tanto de quicio? — Why does his tone get under my skin so much?
Intento que las cosas pequeñas no me saquen de quicio. — I try not to let small things get under my skin.
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