Molestar o irritar a alguien, muchas veces sin querer.
To annoy or irritate someone, often unintentionally.
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See how the word “sacar de quicio” is used in sentences
Su comentario me sacó de quicio. — Her comment really rubbed me up the wrong way.
¿Te saqué de quicio con mi último correo? — Did I rub you up the wrong way with my last email?
No lo saques de quicio llegando tarde. — Please don't rub him up the wrong way by being late.
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