Tener un efecto importante en algo.
To have an important effect on something.
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See how the word “marcar la diferencia” is used in sentences
Las donaciones pequeñas sí marcan la diferencia. — Small donations really make a difference.
¿Un solo voto marca de verdad la diferencia? — Does one vote actually make a difference?
Una palabra amable puede marcar la diferencia para un desconocido. — A kind word can make a difference to a stranger.
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