Così preoccupato o frustrato da non sapere che fare.
So worried or frustrated that you don't know what to do.
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See how the word “non saperne più che fare” is used in sentences
Non ne sapevo più che fare con il computer da riparare. — I was at my wits' end trying to fix my computer.
Non ne sai più che fare con quel progetto difficile? — Are you at your wits' end with that difficult project?
Aiutami, per favore, prima che non ne sappia più che fare! — Please help me before I am at my wits' end!
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