Las circunstancias hacen muy improbable que tengas éxito.
Circumstances make success very unlikely for you.
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See how the word “lo tienes todo en contra” is used in sentences
En el trabajo parece que lo tienes todo en contra. — It feels like the cards are stacked against you at work.
¿Crees que en este partido lo tienes todo en contra? — Do you think the cards are stacked against you in this match?
A veces parece que en la vida todo juega en tu contra. — Sometimes it seems the cards are stacked against you in life.
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